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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

NITROGEN MUSTARD (HYDROCHLORIDE)

VOL.: 9 (1975) (p. 193)

CAS No.: 51-75-2
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanimine

CAS No.: 55-86-7
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanimine hydrochloride

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Nitrogen mustard, administered mainly as the hydrochloride, is carcinogenic in mice and rats. Following its subcutaneous, intraperitoneal or intravenous injection, it produced an increased incidence of lung tumours and thymic lymphomas in mice; it produced a variety of malignant tumours in rats following its intravenous injection.

5.2 Human carcinogenicity data

No case reports or epidemiological studies referring to exposures to nitrogen mustard alone were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (Nitrogen mustard)

Synonyms for Nitrogen mustard

Synonyms for Nitrogen mustard hydrochloride


Last updated: 21 March 1998






















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