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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

MANNOMUSTINE (DIHYDROCHLORIDE)

VOL.: 9 (1975) (p. 157)

CAS No.: 576-68-1
Chem. Abstr. Name: 1,6-Bis(2-chloroethylamino)-1,6-dideoxy-D-mannitol

CAS No.: 551-74-6
Chem. Abstr. Name: 1,6-Bis(2-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Mannomustine administered as the dihydrochloride is carcinogenic in mice following its intraperitoneal injection, producing an increased incidence of leukaemia and a dose-related increase in the incidence of lung tumours.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms for Mannomustine (free base)

Synonyms for Mannomustine (dihydrochloride)


Last updated: 21 March 1998






















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