IPCS INCHEM Home

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CHLORAMBUCIL

VOL.: 9 (1975) (p. 125)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Chlorambucil is carcinogenic in mice and rats following its intraperitoneal injection, producing lymphomas in rats and lymphosarcomas, ovarian tumours and a dose-related increase in the incidence of lung tumours in mice.

5.2 Human carcinogenicity data

The available case reports in which leukaemia and other tumours were reported to have occurred in patients treated with chlorambucil provide insufficient evidence to determine if there is an increased incidence of cancer following the therapeutic use of this drug.

Subsequent evaluation: Vol. 26 (1981); Suppl. 7 (1987)


Last updated: 21 March 1998






















    See Also:
       Toxicological Abbreviations