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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ortho-AMINOAZOTOLUENE

VOL.: 8 (1975) (p. 61)

CAS No.: 97-56-3
Chem. Abstr. Name: 2-Methyl-4 [(2-methylphenyl)azo]-benzenamine

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

ortho-Aminoazotoluene is carcinogenic in mice, rats, hamsters and dogs following its oral administration, producing mainly tumours of the liver, gall-bladder, lung and urinary bladder. It also produced a carcinogenic effect following its administration by other routes in mice and rats. There is some evidence that it produces papillomas of the bladder in rabbits following its administration by direct bladder instillation and in mice after bladder implantation. It is effective in single doses in newborn mice.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 19 March 1998






















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