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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

URETHANE

VOL.: 7 (1974) (p. 111)

CAS No.: 51-79-6

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Urethane has been shown to be carcinogenic in mice, rats and hamsters following administration by the oral, inhalation, subcutaneous or intraperitoneal routes, producing, among others, lung tumours, lymphomas, hepatomas, melanomas and vascular tumours. It is an initiator for skin carcinogenesis in mice both when given orally and topically. It was also shown to enhance the leukaemogenic effect of X-irradiation. It is carcinogenic in single dose experiments and following prenatal exposure. Neonatal and infant mice are more susceptible to cancer induction by urethane than are adult mice.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 19 March 1998






















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