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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

THIOUREA

VOL.: 7 (1974) (p. 95)

CAS No.: 62-56-6

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Thiourea produced liver, thyroid and Zymbal gland tumours in rats following oral administration. Intraperitoneal injection followed by oral administration also led to the formation of Zymbal gland tumours in rats.

Oral and s.c. administration to mice did not produce thyroid tumours; however, the experiment using the s.c. route was inadequate. An increased incidence of liver-cell tumours in trout was reported, but this result cannot be considered as conclusive until additional studies using properly controlled diets are reported.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluations: Suppl. 7 (1987) (p. 72: Group 2B); Vol. 79 (2001)

For definition of Groups, see Preamble Evaluation.

Synonyms for Thiourea


Last updated: 19 March 1998






















    See Also:
       Toxicological Abbreviations
       Thiourea (ICSC)
       Thiourea (CICADS 49, 2003)
       Thiourea  (IARC Summary & Evaluation, Volume 79, 2001)