International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 7 (1974) (p. 85)
CAS No.: 141-90-2
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Thiouracil increased the incidence of liver-cell tumours in mice and
produced thyroid tumours in several strains of rats following oral
administration, the only route tested. Studies in cats, dogs and
monkeys were inadequate in group size and duration to allow evaluation
of carcinogenicity. The study in fish reported did not demonstrate a
significant carcinogenic effect.
5.2 Human carcinogenicity data
No adequate case reports or epidemiological studies were available to
the Working Group.
Subsequent evaluations: Suppl. 7 (1987) (p. 72); Vol. 79 (2001) (p. 127)
For definition of Groups, see Preamble Evaluation.
Synonyms for Thiouracil
Last updated: 20 March 1998