International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 4 (1974) (p. 119)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
N,N-Bis(2-chloroethyl)-2-naphthylamine is carcinogenic to the mouse
lung by the intraperitoneal route and has a local carcinogenic effect
in rats following subcutaneous injection.
5.2 Human carcinogenicity data
This drug has been administered to man with 32P sodium phosphate for
the treatment of polycythaemia and of neoplasias of the haemopoietic
system in doses of up to 400 mg/day. Follow-up studies have shown that
under these conditions, the drug is carcinogenic, producing bladder
tumours after administration of total doses as low as 4 g.
Subsequent evaluation: Suppl. 7 (1987)
Last updated: 16 March 1998