IPCS INCHEM Home

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BIS(CHLOROMETHYL)ETHER

VOL.: 4 (1974) (p. 231)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Bis(chloromethyl)ether (BCME) is carcinogenic to mice following inhalation, skin application and subcutaneous administration. In newborn mice it is carcinogenic after a single subcutaneous exposure. In the rat it is carcinogenic by inhalation and subcutaneous administration.

5.2 Human carcinogenicity data

A high incidence of predominantly oat-cell carcinoma in a small population of laboratory workers exposed to BCME strongly suggests that exposure to this compound constitutes a serious human lung cancer hazard.

There is also epidemiological evidence to suggest that exposure to BCME may constitute a lung cancer risk amongst workers exposed to it as a contaminant in the manufacture of the related chloromethyl methyl ether (CMME) (see separate monograph on CMME).

Subsequent evaluation: Suppl. 7 (1987)


Last updated: 17 March 1998






















    See Also:
       Toxicological Abbreviations
       Griseofulvin  (IARC Summary & Evaluation, Supplement7, 1987)
       Griseofulvin  (IARC Summary & Evaluation, Volume 10, 1976)
       Griseofulvin  (IARC Summary & Evaluation, Volume 79, 2001)