International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 3 (1973) (p. 229)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Indeno(1,2,3-cd)pyrene is a complete carcinogen and an initiator for skin carcinogenesis
in the mouse. It produces local sarcomas in the same species after
subcutaneous injection. It seems to be of lower potency as a skin
carcinogen than benzo(a)pyrene. It has not been tested by other
routes in the mouse or in other species.
5.2 Human carcinogenicity data
No case reports or epidemiological studies on the significance of indeno(1,2,3-cd)pyrene exposure
to man are available. However, coal-tar and other materials
which are known to be carcinogenic to man may contain indeno(1,2,3-cd)pyrene. The
substance has also been detected in other environmental situations.
The possible contribution of polycyclic aromatic hydrocarbons from
some environmental sources to the overall carcinogenic risk to man is
discussed in the General Remarks.
Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 64: Group 2B)
For definition of Groups, see Preamble Evaluation.
Last updated: 16 March 1998