International Agency for Research on Cancer (IARC) - Summaries & Evaluations
DIBENZ(a,h)ACRIDINE
VOL.: 3 (1973) (p. 247)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
In mice, painting with dibenz(a,h)acridine induces skin tumours. Subcutaneous
administration to mice induced local sarcomas and increased the
incidence of lung tumours. It has not been tested adequately by other
routes in the mouse and not at all in other species.
5.2 Human carcinogenicity data
No case reports or epidemiological studies on the significance of
dibenz(a,h)acridine exposure to man are available. However, coal-tar and other
materials which are known to be carcinogenic to man may contain
dibenz(a,h)acridine. The substance has also been detected in other
environmental situations. The possible contributions of heterocyclic
compounds from some environmental sources to the overall carcinogenic
risk to man is discussed in the General Remarks.
Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2B)
For definition of Groups, see Preamble Evaluation.
Last updated: 16 March 1998