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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

SAFROLE, ISOSAFROLE AND DIHYDROSAFROLE

VOL.: 1 (1972) (p. 169)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Safrole and isosafrole are liver carcinogens for the mouse and the rat when administered orally or subcutaneously. Dihydrosafrole is carcinogenic for the oesophagus of the rat following oral administration.

5.2 Human carcinogenicity data

Man may ingest small amounts of safrole and isosafrole through essential oils in which they occur.

No epidemiological data are available on the effects of human exposure.

Subsequent evaluation: Vol. 10 (1976); Suppl. 7 (1987) (p. 62: Dihydrosafrole - Group 2B; p. 65: Isosafrole - Group 3; p. 71: Safrole - Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 16 March 1998






















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