IPCS INCHEM Home

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

NITROSOMETHYLUREA

VOL.: 1 (1972) (p. 125)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Nitrosomethylurea (NMU) is carcinogenic in all six animal species tested. It has a local as well as a systemic carcinogenic effect, producing tumours at different sites, including the nervous tissue. It induces tumours following different routes of administration, including ingestion. It is carcinogenic in single-dose experiments and following prenatal exposure.

5.2 Human carcinogenicity data

The compound may be formed in vivo from methylurea and nitrite or other nitrosating agents. No data on direct human exposure are available.

Subsequent evaluations: Vol. 17 (1978); Suppl. 7 (1987) (p. 66: Group 2A)

For definition of Groups, see Preamble Evaluation.


Last updated: 12 March 1998






















    See Also:
       Toxicological Abbreviations